个人简介:

杜仲坤，男，1987年12月生，博士，副教授，硕士生导师，“1512工程”第三层次。山东农业大学资源与环境学院环境科学与工程系党支部书记，环境科学专业主任，山东省农业环境重点实验室和山东省农业环境污染控制工程技术中心核心成员。

教育背景与工作经历：

教学工作:

主讲本科生课程《环境学导论》、《环境监测B》、《环境化学及生物综合实验》；

主讲研究生课程《环境监测分析》。

研究方向:

新型有机污染物在生物体内的富集、转化及毒性效应；

污染物与土壤微生物相互作用机制；

污染治理与修复。

科研项目:

 1. 国家自然科学基金青年基金项目(41701279)：“卤代咔唑污染物对土壤微生物的影响及其作用规律”，2018.01-2020.12，主持，结题。

 2. 国家重点研发计划子课题(2017YFD0801504)：“镉砷污染土壤调理剂的筛选”，2017.07-2020.12，主持，结题。

 3. 山东省自然科学基金博士基金项目(ZR2017BB075)：“卤代咔唑对斑马鱼心脏发育、神经发育的影响及其分子机制”，2017.08–2019.12，主持，结题。

 4. 中国博士后基金-面上项目(2017M612308)：“卤代咔唑污染物对土壤微生物群落结构及功能的影响”，2017.09-2019.08，主持，结题。

 5. 国家重点研发计划子课题(2016YFD0800202)：“旱地典型农药污染对土壤微生物和土壤动物组成、结构和功能的影响”，2016.01-2020.12，参与，结题。

 6. 国家自然科学基金面上项目(21377050)：“有机磷阻燃剂的鱼体代谢过程及其毒性效应的结构-活性关系”，2014.01-2017.12，参与，结题。

 7. 国家自然科学基金面上项目(21277083)：“咪唑类离子液体对蚯蚓，斑马鱼和小麦的DNA损伤及对抗氧化酶系和解毒酶系的影响”，2013.01-2014.12，参与，结题。

发表论文:

 [1] Baihui Shi, Chao Cheng, Yuanqing Zhang, Zhongkun Du*, Lusheng Zhu, Jun Wang, Jinhua Wang, Bing Li. Effects of 3,6-dichlorocarbazole on microbial ecology and its degradation in soil. Journal of Hazardous Materials. 2022, 424(Part A): 127315. https://doi.org/10.1016/j.jhazmat.2021.127315

 [2] Zhongkun Du^#, Kaixuan Hou^#, Tongtong Zhou, Baihui Shi, Cheng Zhang, Lusheng Zhu*, Bing Li, Jinhua Wang, Jun Wang. Polyhalogenated carbazoles (PHCZs) induce cardiotoxicity and behavioral changes in zebrafish at early developmental stages. Science of The Total Environment. 2022, 841: 156738. https://doi.org/10.1016/j.scitotenv.2022.156738

 [3] Jingwen Zhang, Chao Cheng, Chengbo Lu, Wenxiu Li, Bing Li, Jun Wang, Jinhua Wang, Zhongkun Du*, Lusheng Zhu*. Comparison of the toxic effects of non-task-specific and task-specific ionic liquids on zebrafish. Chemosphere. 2022, 294: 133643. https://doi.org/10.1016/j.chemosphere.2022.133643

 [4] Zhongkun Du^#, Ji Zhang^#, Chao Cheng, Baihui Shi, Lusheng Zhu*, Jun Wang, Jinhua Wang & Bing Li. Effects of 3,6-Dibromocarbazole on Soil Health—Based on Soil Enzymes and the Biolog-ECO Test. Water Air & Soil Pollution. 2022, 233: 256. https://doi.org/10.1007/s11270-022-05736-0

 [5] Jingwen Zhang ¹, Cheng Zhang ¹, Zhongkun Du* , Lusheng Zhu ^⁎, Jun Wang, Jinhua Wang, Bing Li. Emerging contaminant 1,3,6,8-tetrabromocarbazole induces oxidative damage and apoptosis during the embryonic development of zebrafish (Danio rerio). Science of the Total Environment. 2020, 743: 140753. https://doi.org/10.1016/j.scitotenv.2020.140753

 [6] Zhongkun Du, Yanyan Zhu, Lusheng Zhu*, Ji Zhang, Bing Li, Jinhua Wang, Jun Wang, Cheng Zhang, Chao Cheng. Effects of the herbicide mesotrione on soil enzyme activity and microbial communities. Ecotoxicology and Environmental Safety. 2018, 164：571-578. https://doi.org/10.1016/j.ecoenv.2018.08.075

 [7] Zhang Cheng#, Zhongkun Du#, Wang Jinhua, Wang Jun, Zhou Tongtong, Bing Li, Lusheng Zhu*, Li Wenxiu, Hou Kaixuan, Exposed zebrafish (Danio rerio) to imidazolium-based ionic liquids with different anions and alkyl-chain lengths, Chemosphere. 2018, 203: 381-386. https://doi.org/10.1016/j.chemosphere.2018.03.178

 [8] Zhou Tongtong#, Wang Jun#, Ma Zhiqiang, Du Zhongkun*, Zhang Cheng, Zhu Lusheng*, Wang Jinhua, Effects of 1-alkyl-3-methylimidazolium nitrate on soil physical and chemical properties and microbial biomass, Archives of Environmental Contamination and Toxicology. 2018, 74 (4): 1-10. https://doi.org/10.1007/s00244-017-0497-3

 [9] Zhang Cheng#, Wang Jinhua#, Dong Miao, Wang Jun, Du Zhongkun*, Li Bing, Zhu Lusheng*, Effect of 1-methyl-3-hexylimidazolium bromide on zebrafish (Danio rerio), Chemosphere. 2018, 192: 348-353. https://doi.org/10.1016/j.chemosphere.2017.10.169

 [10] Zhongkun Du, Yan Zhang, Guowei Wang, Jianbiao Peng, Zunyao Wang, Shixiang Gao*. TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver. Scientific Reports. 2016, 6: 21827. https://doi.org/10.1038/srep21827

 [11] Zhongkun Du, Guowei Wang, ShixiangGao*, Zunyao Wang. Aryl organophosphate flame retardants induced cardiotoxicity during zebrafish embryogenesis: By disturbing expression of the transcriptional regulators. Aquatic Toxicology. 2015, 161: 25-32. http://dx.doi.org/10.1016/j.aquatox.2015.01.027

 [12] Zhongkun Du, Lusheng Zhu*, Miao Dong, Jinhua Wang, Jun Wang, Hui Xie, Tong Liu, YingyingGuo. Oxidative Stress and Genotoxicity of the Ionic Liquid 1-Octyl-3-Methylimidazolium Bromide in Zebrafish (Danio rerio). Archives of Environmental Contamination and Toxicology. 2014, 67, 261-269. http://dx.doi.org/10.1007/s00244-014-0046-2

 [13] Zhongkun Du, Lusheng Zhu*, Miao Dong, Jinhua Wang, Jun Wang, Hui Xie, Shaoyuan Zhu. Effects of the ionic liquid [Omim]PF₆ on antioxidant enzyme systems, ROS and DNA damage in zebrafish (Danio rerio). Aquatic Toxicology. 2012, 124-125: 91-93. http://dx.doi.org/10.1016/j.aquatox.2012.08.002